The lab focuses on utilization of functional nanomaterials in diagnostic and therapeutic platforms and finds governing principles for biomedical materials design. Ultimate goals are starting from these findings and set a cutting-edge foundation of engineering sophisticated “multiscale biomedical material systems” for translational applications. In order to achieve the goals, we emphasize fundamental understandings of how nano-structured materials interact with biological systems. We also investigate the thermodynamic and kinetic basis of physicochemical interactions between synthetic biomedical materials and complex biological systems, with a specific focus on the surface chemistry and interface engineering.