My lab has two focus areas:
We use the small nematode C. elegans as a model system to understand basic biological questions, related to genome stability, apoptosis, and meiosis. More than half of all C. elegans genes are conserved in humans, and our system benefits from the ease of maintenance, a short generation time of 3 days, the transparency of the nematode, and advanced forward and reverse genetic approaches, all allowing for easy experimentation. Key insights leading to fundamental biological principles and medical applications such as RNAi, miRNAs, apoptosis and whole genome sequencing were first worked out in C. elegans. We are also interested in so called mutational signatures which arise when cells are exposed to DNA damaging agents such as environmental toxins and cancer chemotherapeutic agents. We use C. elegans and human cells for our work. The analysis of mutational patterns provides information about primary mutagenic events and DNA repair pathways that mend DNA damage, and also helps to better understand how chemotherapeutic agents work.
이력
- –2024~present: Associate Member of IBS Center for Genomic Integrity
- –2019: Distinguished Professor at UNIST
- –2019~2023: Associate Director at IBS Center for Genomic Integrity
- -2019~2024: Associated Member, University of Dundee. Scotland
- -2017~2019: Member of the University of Dundee Senate
- -2016~2019: Academic Lead of Dundee University School of Life Sciences Summer School
- -2014: Professor, Chair for Genetics, University of Dundee
- -2010: Reader, University of Dundee
- -2009: Tenure, University of Dundee
- -2004: Lecturer, University of Dundee, Scotland
- -2000: Group Leader, Max Planck Institute for Biochemistry, Martinsried, Germany
- -1997: Postdoctoral Researcher, Cold Spring Harbor Laboratory, New York
- -1996: Postdoctoral Researcher, University of Vienna
- -1996: Social Service Year (Nursing), Rudolfs Hospital, Vienna
학력
- –1995 University of Vienna, PhD
- –1990: University of Vienna, Magister (Master)
논문
- –Hwang T, Sitko LK, …Lee S*, Ivanov D*, Gartner A (2025) Comprehensive whole-genome sequencing reveals origins of mutational signatures associated with aging, mismatch repair deficiency and temozolomide chemotherapy. Nucleic Acids Res. Dec 5:gkae1122.’Co-Corresponding authors
- -Song J”, Geary P”, Hong Y, Rouse J Rolland S’, Gartner A’ (2025) Functional dissection of the conserved C elegans LEM-3/ANKLE 1 nuclease reveals a crucial requirement for the LEM-like and GIY-YIG domains for DNA bridge processing Nucleic Acids Res Mar 20,53(6): gkaf265″ “equal first authors Co-corresponding Authors
- -Volkova NV, Meier B Gartner A” Gerstung M” (2020) Mutational signatures are jointly shaped by DNA damage and repair Nature Commun 11, 1-15 Co-corresponding Authors
수상 / 명예
- –1997: EMBO long-term fellowship, Europe
- –1999: Schrödinger fellowship, Austria
- –2003: CR-UK Career Development Award,
- -2010: Wellcome Trust Senior Research Fellowship
