교수진

조교수
최승원
052-217-3776 seungwon.choi@unist.ac.kr 110동 401-14호
  • 의과학대학원/신경종양 정밀의학 연구실
  • 신경 종양악 정밀의학, 신경교종 종양미세환경
Lab Faculty Research Profile

뇌인지공학

뇌종양은 뇌라는 장기의 특수성으로 인해 다른 암종에 비해 치료 방법이 제한적입니다. 특히 신경교종은 현대 의학의 발전에도 불구하고 치료 성과가 미비한 대표적인 난치성 암입니다.
본 연구실은 환자의 임상 데이터와 다중 오믹스 데이터를 통합적으로 분석하여 뇌종양의 치료 저항성의 원인과 기전을 규명하고, 환자 맞춤형 치료 전략을 제시하는 것을 목표로 하고 있습니다. 특히 신경교종의 유전적 다양성과 종양 미세환경과의 상호작용을 중점적으로 연구하여, 궁극적으로 환자에게 최적화된 치료법을 찾고자 합니다.

이력

  • -2025- Assistant Professor, Graduate School of Health Science and Technology, UNIST
  • –2021-2025, Postdoctoral Research Scientist, Department of Systems Biology, Columbia University
  • –2011-2019, Clinical Fellow, Department of Neurosurgery, Samsung Medical Center, Sunkyunkwan University College of Medicine
  • -2014-2015, Clinical Fellow, Department of Pediatric Neurosurgery, Asan Medical Center, University of Ulsan, College of Medicine
  • -2010-2014, Resident, Department of Neurosurgery, Asan Medical Center, University of Ulsan, College of Medicine

학력

  • –2016-2019, PhD, Health Science and Technology, Sunkyunkwan University
  • –2011-2014, MS, Medicine, University of Ulsan College of Medicine
  • –2003-2009, MD, Ewha Womans University College of Medicine

수상

  • –Academic award (Best paper in basic science), The Korean Brain Tumor Society, 2020
  • –Academic award (Best paper in basic science), The Korean Neurosurgical Society, 2020

논문

  • –A computational framework for mapping isoform landscapes and regulatory mechanisms from spatial transcriptomics data. bioRxiv. 2025 May. https://www.biorxiv.org/content/10.1101/2025.05.02.651907v1
  • –A Multicenter, phase II trial of GC1118, a novel anti-EGFR antibody, for recurrent glioblastoma patients with EGFR amplification. Cancer Medicine. 2023, August. https://doi.org/10.1002/cam4.62
  • -Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma. Cancer Letters. 2023, July 570:216329. 10.1016/j.canlet.2023.216329
  • -Pharmacogenomic profiling reveals molecular features of chemotherapy resistance in IDH wild-type glioblastoma. Genome Medicine. 2023, March. 10.1186/s13073-023-01165-8
  • -Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma. Cell Death & Disease. 2021, April 07;12(4):374
  • -Therapeutic efficacy of GC1118, a novel anti-EGFR antibody, against glioblastoma with high EGFR amplification in patient-derived xenografts. Cancer (Basel). 2020, October 31; 12(11):3210
  • -Hypermuagenesis in untreated adult gliomas due to inherited mismatch mutations. Int J Cancer. 2019 Jun 15;144(12):3023-3030
  • -Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy. Nat Genet. 2018 Oct;50(10):1399-141

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