Molecular Grammar of Biomolecular Phase Separation

Jeong-Mo Choi (E-mail:

Department of Chemistry, Pusan National University, Busan 46241, Republic of Korea


In the last decade, there has been a growing interest on the phase behavior of intrinsically disordered proteins (IDPs), especially after demonstration of its biological implications such as reversible formation/dissociation of membrane-less cellular organelles. Several model systems have been discovered and studied, and one of crucial questions in the field is how the phase behavior is encoded in a sequence. Focusing on a subset of IDPs that apparently exhibit a rather simple molecular grammar for phase behavior, I will present a general theory to predict a critical concentration as a function of motif numbers. Also, I will summarize a recent work that investigates the interactions between scaffold and client molecules and discuss the enhanced proximity effect of membrane-less organelles.


BLDG 110, Rm N104

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