Ghim, Cheol-Min (Ghim, Cheol-Min)
- Associate Professor
- Biochemical Information Processing, Theoretical Biophysics
Current Research Interests
- Physical Biology Biological Physics
- Office : EB4(110) 801-7
- Laboratory : EB4(110) 810
The Ghim Lab seeks to find the “design” principles behind the networks of biological information processing. The networks encompass cellular metabolism, regulation of gene expression, cell-to-cell communication, and up to social and ecological interactions among individuals. The current focus of research is on:
• Control and exploitation of noise in gene expression
• Resource allocation for coordinated metabolism
• Causal inference in neural information transfer
• Socio-economic dynamics in structured populations
The aim from biology side is to rationalize the efficiency and robustness of biological networks in the light of form-function duality. The other side of the coin is an effort to restore the precision and accuracy of biochemical information processing in e.g. synthetic biology or metabolic engineering up to its technological counterpart. Both of these objectives are closely linked to the fundamental problems of equilibrium and nonequilibrium statistical mechanics on complex networks. Information theory and statistical physics are a major tool toward this end but the essential ingredient is still the rigorous biological realism.
Cheol-Min Ghim earned his Ph.D. in theoretical physics from Seoul National University in 2003. After postdoctoral research at Center for Theoretical Physics, SNU (2003-2004), Center for Theoretical Biological Physics, University of California, San Diego (2004-2005), and Levich Institute of Physico-Chemical Hydrodynamics, New York (2005-2006), he had been working for Lawrence Livermore National Laboratory, US Department of Energy (2006-2009). He joined the faculty of UNIST in 2009 as an Assistant Professor of School of Nano-Bioscience & Chemical Engineering and Interdisciplinary School of Green Energy. He holds Visiting Scholar status in US DOE Lawrence Livermore National Laboratory since 2010.
P. Vinuselvi, M. K. Kim, S. K. Lee and C.-M. Ghim, Rewiring carbon catabolite repression for microbial cell factory, BMB Reports, 45, 59 (2012).
R. J. Mitchell, S. K. Lee, T. Kim and C.-M. Ghim, Microbial linguistics: perspectives and applications of microbial cell-to-cell communication, BMB Reports, 44, 1 (2011).
C.-M. Ghim, T. Kim, R. J. Mitchell and S. K. Lee, Synthetic biology for biofuels: Building designer microbes from the scratch, Biotech. Bioproc. Eng. 15, 11 (2010).
C.-M. Ghim and E. Almaas, Two-component genetic circuit as a synthetic module with tunable stability, Phys. Rev. Lett. 103, 028101 (2009).
C.-M. Ghim and E. Almaas, Genetic noise control via protein oligomerization, BMC Sys. Biol. 2, 94 (2008).
C.-M. Ghim, K.-I. Goh, and B. Kahng, Lethality and synthetic lethality in the genome-wide metabolic network of E. coli, J. Theor. Biol. 237, 401 (2005).
T. C. Kim, C.-M. Ghim et al. Kinetic roughening of ion-sputtered Pd(001) surface: Beyond the Kuramoto-Sivashinsky model, Phys. Rev. Lett. 92, 246104 (2004).
C.-M. Ghim and J.-M.Park, Physical model for the gating mechanism of ionic channels, Phys. Rev. E 66, 051910 (2002).